2. Persistence of rabies antibody 5 years after postexopure prophylaxis with Vero Cell antirabies vaccine and antibody response to a single booster dose
来源：本站 日期：2015-07-14
北大人民医院连续5年跟踪调查显示成大速达免疫记忆良好。
Clin Vaccine Immunol. 2011
Sep;18(9):1477-9.
Zhang X1, Zhu Z, Wang C.
· 1Emergency Department, Peking University People's
Hospital, No. 11 Xizhimen South Street, Beijing, China.
Abstract
This study was done to investigate the antibody response to
a Vero cell antirabies vaccine, the persistence of antibody for 5 years,
and the effect of abooster dose after this interval. From August
2005 to February 2011, a total of 195 patients were enrolled into our study due
to an animal bite. The Essen intramuscular (i.m.) regimen, which is recommended
by the WHO for modern vaccines used in postexposure treatment, was adopted in
this study. Blood samples were obtained on day 0, day 7, day 14, day 45, year
1, year 2, year 3, year 4, year 5, and year 5 plus 14 days.
Immunogenicity was evaluated by the titration of neutralizing antibodies with a
rapid fluorescent focus inhibition test (RFFIT). Seroconversion was expressed
as the seroconversion rate (SCR). A secondary quantitative evaluation
criterion, other than the seroconversion level, was the geometric mean titer
(GMT). Of the 195 enrolled patients, 168 (86.4%) of them completed the whole
study. No serious adverse reactions to the vaccine were reported
during vaccination, the 5-year follow-up period, or revaccination. On day
14, the rabies antibody GMT value was 8.87 IU/ml in the vaccinees.
During the next 5 years, the SCR in the ChengDa vaccine group
gradually decreased to 34.0% at year 5, down from 90.5% at year 1. There
was a significant booster effect: the GMT was 15.22 IU/ml on year 5 plus
14 days. Our findings demonstrate that the ChengDa rabies vaccine offers
an alternative with a high degree of efficacy and yet limited side effects and
ensures that the exposed patient will be on the safe side of the risk of rabiesby
the 14th day. Moreover, when followed by a booster dose 5 years later,
it could boost the immunity. A further booster is effective in
inducing a good neutralizing antibody response even after an
interval of 5 years.
